To elucidate the anticancer effect by observing the effect of LAK cells after infusion of IL-2 through splenic artery for the advanced gastrointestinal cancer, randomized study was performed for the 8 patients who had liver metastasis form gastic
and
rectal cancer.
4 patients were performed subtotal gastrectomy for stomach cancer and the others were done abdominoperineal resections for rectal cancer. The liver metastasis were noted all of the cases after sugery between October 1989 and December 1992 at the
Department of Surgery, Keimyung University School of Medicine.
After confirmation of the hepatic metasasis from gastrointestinal cancer, we performed selective splenic arterial infusion of IL-2 with the dosage of 20.000 units/kg B.W.We checked the immune function pre-and post-IL2 infusion therapy, such as
total
lymphocyte count, T-cell percentage and CMI multitest with blood count and hepatorenal function.
There was no difference between the pre-and post IL-2 infusion in the hemoglobin, serum protein, albumin, BUN and creatinin. The total lymphocyte counts of pre-and post IL-2 infusion were 1641.2 and 1727.4, respectively. The T cell percentage of
pre-and
post-IL-2 infusion were 62.51% and 64.27%, respectively and had the tendency to increase in comparison with pre-IL-2 infusion, but there were not stastical differences. The results of CMI multitest of pre-and post IL-2 infusion were not definite
differences.
From the above results, it could be suggested that LAK cell after infusion of IL-2 via selective splenc artery had the slightly positive effect of the immune function of advanced gastrointestinal cancer patient, with hepatic metastasis.
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